The GenTAC Alliance is a division of The Marfan Foundation.
The GenTAC Alliance builds upon the successes of the GenTAC Registry, which enrolled and followed participants from 2006 to 2016.
The Alliance aims to identify knowledge gaps in the treatment of genetic aortic and vascular conditions; convene researchers and healthcare professionals working in this space; increase the understanding of these conditions by healthcare professionals, leading to better patient outcomes worldwide; and accelerate the pace of research focused on these conditions.
Featured Events & Content
Imaging findings of Marfan syndrome: What radiologists need to know
In a recent article for Aunt Minnie, Sanjeev Bhalla, MD, and Mensur Koso, MD, both from the…
Dr. Alan Braverman Discusses Important Role Radiologists Play in Early Marfan Diagnosis
Dr. Alan Braverman, director of the Marfan Syndrome and Aortopathy Center at the Washington…
Genetic Variation in BAV and Its Role in Aortic Stenosis and Aneurysmal Disease
The GenTAC Alliance’s Basic and Translational Science Working Group hosted a webinar on January…
Integrating Mental Health Screening into Aortopathy Care
Thoracic aortic disease (TAD) is associated with significant cardiovascular complications that…
Highlights from Tromsø Aorta 2024
On October 15, Dr. Kim Eagle, GenTAC chair and director of the Frankel Cardiovascular Center at…
Aortic Dissection Awareness Week
Aortic Dissection Awareness Week is a time when we especially focus on helping everyone understand…
GenTAC Aortic Summit
The GenTAC Aortic Summit is one of the premier meetings in the world focused on sharing knowledge…
Management of Aortopathy in Children
On August 12, 2024, the American Heart Association (AHA) published the first comprehensive…
Single-cell Transcriptomics Webinar
The GenTAC Alliance Basic and Translational Science Working Group held a webinar titled,…
Upcoming & Past Webinars
Genetic Variation in Bicuspid Aortic Valve (BAV)
In this webinar from January 16, 2025, Dr. Simon Body of Boston University shares the recent results of a large multi-center study on the genetic associations with bicuspid aortic valve (BAV) disease. He also covers the implications of these findings for the observed high frequency of calcific aortic valve disease and aortic aneurysm in individuals with BAV.
Integrating Mental Health Screening into Aortopathy Care
In this webinar, Sharon Zachariah, BS, and Siddharth Prakash, MD, PhD, both of UTHealth Houston, discuss their innovative approach to incorporating mental health screenings into thoracic aortic disease (TAD) care. They share the program’s outcomes and discuss how it can be standardized in clinics worldwide to improve the mental health of individuals with TAD.
Highlights from Tromsø Aorta 2024
On October 15, 2024, Dr. Kim Eagle, GenTAC chair and director of the Frankel Cardiovascular Center at University of Michigan, shared key insights from the 8th GenTAC Aortic Summit held in Tromsø, Norway in August.
Molecular and cellular dynamics in aortic diseases: New insights from single-cell transcriptomic studies
In this webinar from March 7, 2024, speakers discussed the latest discoveries gained from single-cell transcriptomic studies, focusing on the changes in aortic cells and inflammatory cells during the development of aortic aneurysms and aortic dissection.
Sexual Dimorphism in Thoracic Aortic Disease
Webinar speakers present evidence of sexual dimorphism in heritable thoracic aortic disease in both animal models and humans.
Accessing GenTAC Data and Biospecimens Using BioLINCC
This webinar covers the process for accessing data and biospecimens from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) available through BioLINCC.
Exploiting Advantages of the Zebrafish Model for the Study of Aortopathies
This webinar covers recent progress with mutant zebrafish models, including their ability to provide clinically pertinent clues regarding true pathogenecity.
Transcriptional and Epigenetic Factors in the Generation of Thoracic Aortic Disease
Experts in the field of epigenetics and transcriptional mechanics of the ascending aorta discuss their research and its implications in the generation of thoracic aortic disease (TAD) in patients with a bicuspid aortic valve (BAV).
iPSC Models of Thoracic Aortopathies: Possibilities and Challenges
This webinar provides state of the art examples of using induced pluripotent stem (iPS) cells for modeling thoracic aortic disease in Loeys-Dietz syndrome and Marfan syndrome.
